Title of article
Homo- and heterogeneous Ru-based metathesis catalysts in cross-metathesis of 15-allylestrone—towards 17β-hydroxysteroid dehydrogenase type 1 inhibitors
Author/Authors
Kirschning، نويسنده , , Andreas and Harmrolfs، نويسنده , , Kirsten and Mennecke، نويسنده , , Klaas and Messinger، نويسنده , , Josef and Schِn، نويسنده , , Uwe and Grela، نويسنده , , Karol، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3019
To page
3022
Abstract
The cross-metathesis of allylestrone with acrylic acid derivatives using homogeneous and heterogenized Ru-catalysts was evaluated for the synthesis of a new 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Hoveyda-type catalyst containing an additional diethylamino group turned out to be comparably active as homogeneous Grubbs II catalyst after immobilization on an acidic ion exchange resin which greatly facilitated workup.
Keywords
Catalysis , Cross-olefin metathesis , Immobilization , Ru-catalyst , Steroids , enzyme inhibitor
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859129
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