Author/Authors :
Kirschning، نويسنده , , Andreas and Harmrolfs، نويسنده , , Kirsten and Mennecke، نويسنده , , Klaas and Messinger، نويسنده , , Josef and Schِn، نويسنده , , Uwe and Grela، نويسنده , , Karol، نويسنده ,
Abstract :
The cross-metathesis of allylestrone with acrylic acid derivatives using homogeneous and heterogenized Ru-catalysts was evaluated for the synthesis of a new 17β-hydroxysteroid dehydrogenase type 1 inhibitor. Hoveyda-type catalyst containing an additional diethylamino group turned out to be comparably active as homogeneous Grubbs II catalyst after immobilization on an acidic ion exchange resin which greatly facilitated workup.
Keywords :
Catalysis , Cross-olefin metathesis , Immobilization , Ru-catalyst , Steroids , enzyme inhibitor
