Title of article :
A P∗-chiral bisdiamidophosphite ligand with a 1,4:3,6-dianhydro-d-mannite backbone and its application in asymmetric catalysis
Author/Authors :
Gavrilov، نويسنده , , Konstantin N. and Zheglov، نويسنده , , Sergey V. and Vologzhanin، نويسنده , , Pavel A. and Maksimova، نويسنده , , Marina G. and Safronov، نويسنده , , Anton S. and Lyubimov، نويسنده , , Sergey E. and Davankov، نويسنده , , Vadim A. and Schنffner، نويسنده , , Benjamin and Bِrner، نويسنده , , Armin، نويسنده ,
Abstract :
A novel readily available P,P-bidentate diamidophosphite ligand with P∗-stereocentres is prepared from an inexpensive C2-symmetric 1,4:3,6-dianhydro-d-mannite. By using this efficient ligand, up to 98% ee is achieved in Pd-catalysed asymmetric allylic alkylation, up to 92% ee in Pd-catalysed asymmetric allylic amination and up to 87% ee in Rh-catalysed asymmetric hydrogenation. The influence of the precatalyst, substrate and solvent on the enantioselectivity is discussed.
Keywords :
Rhodium , PALLADIUM , Hydrogenation , amination , Asymmetric reactions , Phosphorus ligands
