Title of article :
Microwave-assisted synthesis of pyrazolo[3,4-d]pyrimidines from 2-amino-4,6-dichloropyrimidine-5-carbaldehyde under solvent-free conditions
Author/Authors :
Quiroga، نويسنده , , Jairo and Trilleras، نويسنده , , Jorge and Insuasty، نويسنده , , Braulio and Abonيa، نويسنده , , Rodrigo and Nogueras، نويسنده , , Manuel and Marchal، نويسنده , , Antonio and Cobo، نويسنده , , Justo، نويسنده ,
Abstract :
The microwave-induced synthesis of pyrazolo[3,4-d]pyrimidines 4 in the reaction of N4-substituted-2,4-diamino-6-chloro-5-carbaldehydes 3 with hydrazine is described here. Precursors 3 have been prepared by the mono-amination of 2-amino-4,6-dichloropyrimidine-5-carbaldehyde 2 with aliphatic and aromatic amines. The reaction times with primary amines were relatively shorter than for secondary amines.
