Author/Authors :
Grée، نويسنده , , Danielle and Vorin، نويسنده , , Samuel and Manthati، نويسنده , , Vijay L. and Caijo، نويسنده , , Frédéric and Viault، نويسنده , , Guillaume and Manero، نويسنده , , Florence and Juin، نويسنده , , Philippe and Grée، نويسنده , , René، نويسنده ,
Abstract :
A new and versatile strategy has been developed towards HA 14-1 analogues, selectively modified on position 4 and/or on the primary amine function. An important aspect was the appropriate selection of the phenol protective group in the 5-bromosalicylaldehyde, allowing the isolation of the key intermediate the 2H-benzopyrane-2-imine 2′.
Keywords :
HA 14-1 , bcl-2 , Anticancer , Benzopyrane
