Title of article
Pyridine analogs of (−)-cytisine and varenicline: cholinergic receptor probes
Author/Authors
Demers، نويسنده , , Sebastien and Stevenson، نويسنده , , Heather and Candler، نويسنده , , John and Bashore، نويسنده , , Crystal G. and Arnold، نويسنده , , Eric P. and O’Neill، نويسنده , , Brian T. and Coe، نويسنده , , Jotham W. Coe، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
3368
To page
3371
Abstract
A series of bicyclic pyridine containing alkaloids related to (−)-cytisine and varenicline are described. Synthetic access via regioisomeric metalation of alkoxy- and halo-pyridines gains entry to all four isomeric [3.3.1]-bicyclic targets. Regioselective and sequential oxidative cleavage of dicyclopentadiene generates a related [3.2.1]-bicyclic analog.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859279
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