Author/Authors :
Demers، نويسنده , , Sebastien and Stevenson، نويسنده , , Heather and Candler، نويسنده , , John and Bashore، نويسنده , , Crystal G. and Arnold، نويسنده , , Eric P. and O’Neill، نويسنده , , Brian T. and Coe، نويسنده , , Jotham W. Coe، نويسنده ,
Abstract :
A series of bicyclic pyridine containing alkaloids related to (−)-cytisine and varenicline are described. Synthetic access via regioisomeric metalation of alkoxy- and halo-pyridines gains entry to all four isomeric [3.3.1]-bicyclic targets. Regioselective and sequential oxidative cleavage of dicyclopentadiene generates a related [3.2.1]-bicyclic analog.
