Title of article
Regioselective Pd-catalyzed indolization of 2-bromoanilines with internal alkynes using phosphine-free ligands
Author/Authors
Cui، نويسنده , , Xin and Li، نويسنده , , Juan and Fu، نويسنده , , Yao and Liu، نويسنده , , Ting-Lei and Guo، نويسنده , , Qing-Xiang، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
5
From page
3458
To page
3462
Abstract
The possibility of using phosphine-free ligands to promote Pd-catalyzed indolization of 2-bromoanilines with internal alkynes was examined for the first time. Phenylurea was found to be the optimal ligand, which could mediate the synthesis of 2,3-disubstituted indoles in good yields (ca. 60–85%) with high regioselectivity.
Keywords
indole , Larock indolization , palladium catalyst , Phosphine-free ligand , heteroannulation
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859323
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