Author/Authors :
Tarui، نويسنده , , Atsushi and Ozaki، نويسنده , , Daiki and Nakajima، نويسنده , , Naoko and Yokota، نويسنده , , Yuto and Sokeirik، نويسنده , , Yasser S. and Sato، نويسنده , , Kazuyuki and Omote، نويسنده , , Masaaki and Kumadaki، نويسنده , , Itsumaro and Ando، نويسنده , , Akira، نويسنده ,
Abstract :
We developed a new methodology for the asymmetric Reformatsky-type reaction of (−)-menthyl bromodifluoroacetate (2) with imine in the presence of RhCl(PPh3)3. Ester 2 with the cost-effective chiral auxiliary gave (S)-difluoro-β-lactams in moderate to good yields and high diastereoselectivities through spontaneous removal of the auxiliary.
Keywords :
Diethylzinc , chiral auxiliary , fluorine , Rhodium , Difluoro-?-lactam , Imine , Reformatsky-type reaction
