Author/Authors :
Kudoh، نويسنده , , Takashi and Weber، نويسنده , , Karin and Guse، نويسنده , , Andreas H. and Potter، نويسنده , , Barry V.L. and Hashii، نويسنده , , Minako and Higashida، نويسنده , , Haruhiro and Arisawa، نويسنده , , Mitsuhiro and Matsuda، نويسنده , , Akira and Shuto، نويسنده , , Satoshi، نويسنده ,
Abstract :
4″,6″-Didehydro-cADPcR (3), an unsaturated carbocyclic ribose analog of a Ca2+-mobilizing second messenger cyclic ADP-ribose (cADPR), was designed and successfully synthesized using a key intramolecular condensation reaction forming the 18-membered pyrophosphate ring structure with a S-phenyl phosphorothioate-type substrate. Biological evaluation showed that 4″,6″-didehydro-cADPcR is a potent Ca2+-mobilizing agent in T cells.
