Title of article :
A novel and efficient domino reaction for the one-pot synthesis of spiro-2-aminopyrimidinones
Author/Authors :
Ramezanpour، نويسنده , , Sorour and Hashtroudi، نويسنده , , Mehri Seyed and Bijanzadeh، نويسنده , , Hamid Reza and Balalaie، نويسنده , , Saeed، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
A novel and efficient protocol is developed for the synthesis of various spiro-2-amino pyrimidinones via the three-component condensation of alkyl cyanoacetates, guanidinium carbonate and N-substituted 4-piperidinones in ethanol at reflux. High yields, neutral conditions, and short reaction times are advantages of this method.
Keywords :
One-pot three-component reaction , Domino reaction , Guanidinium carbonate , Spiro-2-aminopyrimidinones , Domino Knoevenagel-cyclocondensation , Neutral conditions
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
