Title of article :
Enantiodivergent synthesis of trans-3,4-disubstituted succinimides by SmI2-mediated Reformatsky-type reaction
Author/Authors :
Lin، نويسنده , , Geng-Jie and Luo، نويسنده , , Shi-Peng and Zheng، نويسنده , , Xiao and Ye، نويسنده , , Jian-Liang and Huang، نويسنده , , Pei-Qiang، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
An enantiodivergent strategy for the synthesis of trans-3,4-disubstituted succinimides is reported. The key step is a highly trans-stereoselective SmI2-induced Reformatsky-type reaction of 4-substituted-O-benzoylated malimides with carbonyl compounds. Double chirality transmissions were performed with good to excellent diastereoselectivities.
Keywords :
succinimides , Reformatsky-type reaction , Samarium diiodide , Chiral relay , enantioselective synthesis
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
