Title of article :
The first total synthesis and structural determination of TMC-264
Author/Authors :
Tatsuta، نويسنده , , Kuniaki and Furuyama، نويسنده , , Akiho and Yano، نويسنده , , Tomoe and Suzuki، نويسنده , , Yasuaki and Ogura، نويسنده , , Takashi and Hosokawa، نويسنده , , Seijiro، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
The first total synthesis and structural determination of TMC-264 has been accomplished. Regioselective bromination, regioselective methoxymethylation, and nickel(0)-Lewis acid-mediated cyclization afforded multi-functionalized 1-methyl-dibenzo[b,d]-pyran skeleton.
Keywords :
total synthesis , absolute configuration , Antiallergic agent , Regioselective methoxymethylation , Biaryl coupling , TMC-264
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
