Author/Authors :
Vesely، نويسنده , , Jan and Zhao، نويسنده , , Gui-Ling and Bartoszewicz، نويسنده , , Agnieszka and Cَrdova، نويسنده , , Armando، نويسنده ,
Abstract :
A novel organocatalytic highly enantioselective nitrocyclopropanation reaction of α,β-unsaturated aldehydes is presented. The 1-nitro-2-formylcyclopropane derivatives synthesized from this catalytic transformation were converted to the corresponding β-nitromethyl-acid esters, which are excellent precursors of GABA analogues such as Baclofen, by subsequent organocatalytic chemoselective ring-opening.
