Author/Authors :
P?cha، نويسنده , , Jan and Bud???nsk?، نويسنده , , Milo? and ?anda، نويسنده , , Miloslav and Jir??ek، نويسنده , , Ji??، نويسنده ,
Abstract :
The synthesis of norleucine-derived phosphonopeptides was achieved by BOP-catalyzed coupling of the monobenzyl ester of a N-CBz-protected phosphonate derivative of norleucine with hydroxyl moieties of derivatized lactic or glycolic acids. The complete deprotection of the product esters/carbamates was achieved in good yields by one-step Pd-catalyzed hydrogenolysis.
