Title of article
Zinc cyanide mediated direct α-cyanation of isonicotinic acid N-oxide. Application to the synthesis of FYX-051, a xanthine oxidoreductase inhibitor
Author/Authors
Huo، نويسنده , , Zhibao and Kosugi، نويسنده , , Teruo and Yamamoto، نويسنده , , Yoshinori، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
4369
To page
4371
Abstract
Reaction of isonicotinic acid N-oxide 1a with dimethylcarbamoyl chloride and zinc cyanide in CH3CN at 120 °C gave the corresponding 2-cyanoisonicotinamide 2a in a good yield. This strategy was applied to the synthesis of FYX-051·TsOH 8, a xanthine oxidoreductase inhibitor.
Keywords
Zinc cyanide , ?-Cyanation , Pyridine N-oxide , 2-Cyanoisonicotinamide , Isonicotinic acid N-oxide
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1859754
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