Title of article :
Aminomethylation of lithiated nicotinamide: access to new pyridolactams
Author/Authors :
Prieur، نويسنده , , Emilie and Azzouz، نويسنده , , Rabah and Deguest، نويسنده , , Geoffrey and Fruit، نويسنده , , Corinne and Bischoff، نويسنده , , Laurent and Marsais، نويسنده , , Francis، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
New 2,3-dihydropyrrolopyridinones were conveniently prepared by trapping lithiated pyridine carboxamides with highly reactive formimines. In this Letter, we report that a wide range of N-functionalised compounds can be synthesised in one step by this process, allowing the presence of ethers, acetals or ester moieties.
Keywords :
pyridine , Lactam , Aminomethylation , Formimine , Metalation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
