Author/Authors :
Konno، نويسنده , , Hiroyuki and Okuno، نويسنده , , Yasuhiro and Makabe، نويسنده , , Hidefumi and Nosaka، نويسنده , , Kazuto and Onishi، نويسنده , , Akio and Abe، نويسنده , , Yoshinari and Sugimoto، نويسنده , , Atsuya and Akaji، نويسنده , , Kenichi، نويسنده ,
Abstract :
Total synthesis of cis-solamin A was accomplished without using protecting groups starting from (−)-muricatacin in 11 steps with an overall yield of 4.5%. The backbone of cis-solamin A was constructed by olefin cross-metathesis between the tetrahydrofuran moiety and γ-lactone moiety. An enzymatic kinetic transesterification procedure was successfully applied to the synthesis of an optically pure γ-lactone moiety.
Keywords :
Annonaceous acetogenin , Enzymatic transesterification , cross-metathesis , Solamin , Mitochondrial complex I inhibitor
