Title of article :
Efficient synthesis of 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters
Author/Authors :
Murphy، نويسنده , , Douglas E. and Dragovich، نويسنده , , Peter S. and Ayida، نويسنده , , Benjamin K. and Bertolini، نويسنده , , Thomas M. and Li، نويسنده , , Lian-Sheng and Ruebsam، نويسنده , , Frank and Stankovic، نويسنده , , Nebojsa S. and Sun، نويسنده , , Zhongxiang and Zhao، نويسنده , , Jingjing and Zhou، نويسنده , , Yuefen، نويسنده ,
Abstract :
A general procedure is described for the preparation of 6-substituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (6-substituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters). These compounds are shown to undergo selective alkylation at the 2-position in moderate to good yields (19–77%) to afford 2,6-disubstituted-5-hydroxy-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid ethyl esters (2,6-disubstituted-5-hydroxy-3(2H)-pyridazinone-4-carboxylic acid ethyl esters).
Keywords :
?-Keto-ester , ?-Hydrazono-ester , Pyridazinone , Dieckmann cyclization , Selective alkylation
