Title of article
[15N]-Isotopic labeling: a suitable tool to study the reactivity of bis lactams
Author/Authors
Coursindel، نويسنده , , Thibault and Farran، نويسنده , , Daniel and Martinez، نويسنده , , Jean and Dewynter، نويسنده , , Georges، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
906
To page
909
Abstract
The unexpected reactivity of 2,5-diketopiperazines under basic conditions, thanks to N-Boc activation, allows access to valuable pharmacological scaffolds, such as original statine derivatives. Toward this transannular rearrangement of activated lactams (TRAL), we report here the study of bis lactam reactivity using [15N]-isotopic labeling.
Keywords
Diketopiperazine , Lactam activation , TRAL , stereoselective synthesis
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860241
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