[15N]-Isotopic labeling: a suitable tool to study the reactivity of bis lactams

The unexpected reactivity of 2,5-diketopiperazines under basic conditions, thanks to N-Boc activation, allows access to valuable pharmacological scaffolds, such as original statine derivatives. Toward this transannular rearrangement of activated lactams (TRAL), we report here the study of bis lactam reactivity using [15N]-isotopic labeling.