Author/Authors :
Wan ، نويسنده , , Yi and Yuan، نويسنده , , Shifang and Xue، نويسنده , , Xiaochang and Li، نويسنده , , Meng and Qin، نويسنده , , Xin and Zhang، نويسنده , , Cun and Wang، نويسنده , , Weihua and Jiang، نويسنده , , Changli and Wu، نويسنده , , Shouzhen and Liu، نويسنده , , Yan and Zhu، نويسنده , , Wenhua and Ran، نويسنده , , Yonggang and Zhang، نويسنده , , Zhen and Han، نويسنده , , Wei and Zhang، نويسنده , , Yingqi، نويسنده ,
Abstract :
Adjuvants are necessary to elicit high titers of antibodies in vaccine-immunization procedures. We previously developed a mouse tumor necrosis factor-α (TNF-α) autovaccine (mTNF-PADRE) capable of inducing anti-TNF-α antibodies. In this study, we investigated the therapeutic effect of adjuvant-free administration of the autovaccine on collagen-type-II-induced rheumatoid arthritis (CIA) in mice. Our results showed that the vaccine could ameliorate the symptoms of CIA in mice. In addition, this study suggests that it is possible to control the antibody levels in mice immunized with mTNF-PADRE without adjuvant.
Keywords :
Mouse TNF-? autovaccine , Adjuvant , rheumatoid arthritis , Therapeutic effect
