Title of article
Development of the first and practical method for enantioselective synthesis of 10B-enriched p-borono-l-phenylalanine
Author/Authors
Hattori، نويسنده , , Yoshihide and Asano، نويسنده , , Tomoyuki and Kirihata، نويسنده , , Mitsunori and Yamaguchi، نويسنده , , Yoshihiro and Wakamiya، نويسنده , , Tateaki، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
4977
To page
4980
Abstract
At present p-(10B)borono-l-phenylalanine (l-10Bpa) is used clinically as an excellent 10B carrier for BNCT; however, its enantioselective synthesis has not been reported yet. The present Letter describes the first and practical method for enantioselective synthesis of 10B-enriched l-Bpa using Z-l-Ser–OMe as the chiral synthon in good total yield and high optical purity.
Keywords
BNCT , p-Boronophenylalanine , enantioselective synthesis , 8-Diaminonaphtalene , 1
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860615
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