Enantioselective synthesis of phomallenic acid C, an inhibitor of FAS II pathway

Enantioselective synthesis of phomallenic acid C, an inhibitor of bacterial FAS II pathway, was successful. Allenyldiyne structure was constructed by a direct anti-SN2′ coupling of propargyl mesylate with diynylindium in the presence of palladium catalyst. Enantiomeric purity was determined by Ohrui–Akasaka method to be 83%ee.