Title of article :
Lipoic acid attenuates high fat diet-induced chronic oxidative stress and immunosuppression in mice jejunum: A microarray analysis
Author/Authors :
Cui، نويسنده , , Jue and Le، نويسنده , , Guowei and Yang، نويسنده , , Ruili and Shi، نويسنده , , Yonghui، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2009
Pages :
7
From page :
44
To page :
50
Abstract :
A high fat diet (HFD) has long been linked to immune dysfunction, including diminished numbers or reactivity of lymphocytes, increased susceptibility to infection, inhibited lymphocytes function during antigen-specific responses and developed oxidative stress. Whereas the molecular mechanistic events associated with immune deficiency remain to be fully determined. Using the DNA microarray system, we analyzed the gene expression patterns of lymphocyte related signal transduction proteins in jejunum of C57BL/6 mice in order to gain insight on the possible molecular mechanism by which HFD induced oxidative stress effects on signal transduction of lymphocytes. Results of present study showed that HFD induced oxidative stress and immunosuppression in jejunum. Antioxidant lipoic acid (LA) supplement ameliorated that HFD induced oxidative stress and immunosuppression by recovering transcriptional levels of the gene involved in B cell receptor, T cell differentiation signaling pathway, and free radical scavengers. The present study indicates that a HFD can induce chronic oxidative stress, suppress signal transduction of gut-associated lymphocytes, and lead to an inhibition of mucosal immunity.
Keywords :
Lipoic acid , Chronic oxidative stress , Jejunum , DNA microarray , B cell receptor signaling pathway , T cell differentiation , Free radical scavenger , high fat diet
Journal title :
Cellular Immunology
Serial Year :
2009
Journal title :
Cellular Immunology
Record number :
1860686
Link To Document :
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