Title of article :
A synthesis of licofelone using Fenton’s reagent
Author/Authors :
R?dl، نويسنده , , Stanislav and ?ern?، نويسنده , , Josef and Klec?n، نويسنده , , Ond?ej and Stach، نويسنده , , Jan and Pla?ek، نويسنده , , Luk?? and Mandelov?، نويسنده , , Zuzana، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
An efficient synthesis of licofelone, an anti-inflammatory drug currently undergoing phase-III clinical studies, based on Fenton-type radical alkylation of 2,3-dihydro-1H-pyrrolizine 3 with iodoacetonitrile or iodoacetates is reported. The iodoacetates can be replaced by NaI and by the corresponding bromoacetate.
Keywords :
Fenton’s reagent , Licofelone esters , Licofelone nitrile , Licofelone amide , spectral characterization , Licofelone , Radical reaction
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
