Title of article
A facile route to the pentacyclic lamellarin skeleton via Grob reaction between 3-nitro-2-(trifluoromethyl)-2H-chromenes and 1,3,3-trimethyl-3,4-dihydroisoquinolines
Author/Authors
Korotaev، نويسنده , , Vladislav Yu. and Sosnovskikh، نويسنده , , Vyacheslav Ya. and Kutyashev، نويسنده , , Igor B. and Barkov، نويسنده , , Alexey Yu. and Shklyaev، نويسنده , , Yurii V.، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
5376
To page
5379
Abstract
The basic structural framework of lamellarin alkaloids, 8,9-dihydro-6H-chromeno[4′,3′:4,5]pyrrolo[2,1-a]isoquinoline derivatives, has been obtained in good yields via Grob reaction between 3-nitro-2-(trifluoromethyl)-2H-chromenes and 1,3,3-trimethyl-3,4-dihydroisoquinolines in refluxing isobutanol. When the reaction was carried out in toluene at room temperature, only Michael adducts, as a mixture of two diastereomers, were isolated.
Keywords
3-Nitro-2-(trifluoromethyl)-2H-chromenes , Lamellarin skeleton , Grob reaction , 1 , 3 , 3-Trimethyl-3 , 4-Dihydroisoquinolines
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1860793
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