Title of article :
Preparation of MBHA resin by benzotriazole-mediated amidoalkylation
Author/Authors :
Lee، نويسنده , , Tae-Kyung and Choi، نويسنده , , Jeong-Hyun and Byun، نويسنده , , Jang-Woong and Lee، نويسنده , , Yoon-Sik، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
MBHA (4-methylbenzhydrylamine) resin is widely used as a solid support for the synthesis of carboxamides or peptide C-terminal amides. Herein, we report a new method for synthesizing MBHA resin by benzotriazole-mediated amidoalkylation. MBHA resin was efficiently prepared with N-[(benzotriazol-1-yl)(p-tolyl)methyl]formamide or N-[formamido(p-tolyl)methyl]formamide, and it showed excellent properties as a solid support.
Keywords :
Solid-phase peptide synthesis , MBHA resin , 1-Benzotriazole , Amidoalkylation
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
