Title of article
IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan
Author/Authors
Wallet، نويسنده , , Mark A. and Wallet، نويسنده , , Shannon M. and Guiulfo، نويسنده , , Giorgio and Sleasman، نويسنده , , John W. and Goodenow، نويسنده , , Maureen M.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2010
Pages
5
From page
84
To page
88
Abstract
The objective was to assess outcomes of IFNγ-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNγ and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNγ-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNγ suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNγ modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion.
Keywords
tumor necrosis factor , C-jun , rheumatoid arthritis , inflammation , Hyaluronan , Interleukin-12 , macrophages , Interferon Gamma , Interleukin-10
Journal title
Cellular Immunology
Serial Year
2010
Journal title
Cellular Immunology
Record number
1860814
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