Title of article :
IFNγ primes macrophages for inflammatory activation by high molecular weight hyaluronan
Author/Authors :
Wallet، نويسنده , , Mark A. and Wallet، نويسنده , , Shannon M. and Guiulfo، نويسنده , , Giorgio and Sleasman، نويسنده , , John W. and Goodenow، نويسنده , , Maureen M.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2010
Abstract :
The objective was to assess outcomes of IFNγ-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNγ and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNγ-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNγ suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNγ modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion.
Keywords :
tumor necrosis factor , C-jun , rheumatoid arthritis , inflammation , Hyaluronan , Interleukin-12 , macrophages , Interferon Gamma , Interleukin-10
Journal title :
Cellular Immunology
Journal title :
Cellular Immunology
