Author/Authors :
Alyamkina، نويسنده , , Ekaterina A. and Dolgova، نويسنده , , Evgenia V. and Likhacheva، نويسنده , , Anastasia S. and Rogachev، نويسنده , , Vladimir A. and Sebeleva، نويسنده , , Tamara E. and Nikolin، نويسنده , , Valeriy P. and Popova، نويسنده , , Nelly A. and Kiseleva، نويسنده , , Elena V. and Orishchenko، نويسنده , , Konstantin E. and Sakhno، نويسنده , , Ludmila V. and Gel’fgat، نويسنده , , Evgeniy L. and Ostanin، نويسنده , , Alexandr A. and Chernykh، نويسنده , , Elena R. and Zagrebelniy، نويسنده , , Stanislav N. and Bogachev، نويسنده , , Sergey S. and Shurdov، نويسنده , , Mikhail A.، نويسنده ,
Abstract :
Exogenous allogenic DNA as nucleosome-free fragments reaches main cellular compartments (cytoplasm, nucleus) of human dendritic cells and deposits in the nuclear interchromosomal space without visibly changing in linear size. The presence of such allogenic fragmented DNA in medium in which human dendritic cells are cultured produces an enhancement of their allostimulatory activity. This enhancement is comparable to that produced by the standard maturation stimulus lipopolysaccharide Escherichia coli.
Keywords :
Nucleosome-free fragmented dsDNA , Lung tuberculosis , Allostimulatory activity , Mononuclear cells
