Author/Authors :
Quiroga، نويسنده , , Jairo and Trilleras، نويسنده , , Jorge and Gلlvez، نويسنده , , Jaime and Insuasty، نويسنده , , Braulio and Abonيa، نويسنده , , Rodrigo and Nogueras، نويسنده , , Manuel and Cobo، نويسنده , , Justo and Marchal، نويسنده , , Antonio، نويسنده ,
Abstract :
A series of 6-aminopyrimidines are cyanoacetylated with a mixture of cyanoacetic acid and acetic anhydride. When pyrimidin-4(3H)-ones are used as substrates, the substitution occurs at C-5, however, when the substrates are substituted pyrimidines at the C-2 and C-4, the cyanoacetylation takes place at the exocyclic amino group.
