Title of article
Preparation of a set of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones as potential Hsp90 ligands
Author/Authors
Semeraro، نويسنده , , Teresa and Mugnaini، نويسنده , , Claudia and Corelli، نويسنده , , Federico، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
5965
To page
5967
Abstract
A synthetic route for the preparation of 4,5-dihydro-3H-pyrrolo[3,2-d]pyrimidin-4-ones characterized by a decorated benzyl moiety at different positions of the five-membered ring has been developed, and some compounds have been tested as Hsp90 ligands. One of them displayed IC50 = 50 μM representing an interesting starting point for further investigations.
Keywords
Hsp90 ligands , 2-d]pyrimidin-4-ones , Deazapurines
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861124
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