Author/Authors :
Singh، نويسنده , , Sheo B. and Herath، نويسنده , , Kithsiri and Yu، نويسنده , , Nathan X. and Walker، نويسنده , , Andre A. and Connors، نويسنده , , Neal، نويسنده ,
Abstract :
Nocathiacin-I is one of the newest members of thiazolyl peptide class of antibiotics. It is a potent inhibitor of bacterial protein synthesis and showed potent in vitro and in vivo Gram-positive antibacterial activity. Understanding of the biosynthesis of natural products is important for improvement of titer and precursor directed biosynthesis for new compounds. Biosynthesis of nocathiacin-I in Amycolatopsis fastidiosa using stable isotope precursor incorporation is described.
