Title of article
Design, synthesis, and biological evaluation of a dansyled amino acid derivative as an imaging agent for apoptosis
Author/Authors
Zeng، نويسنده , , Wenbin and Miao، نويسنده , , Weimin and Kabalka، نويسنده , , George and Puil، نويسنده , , Michael Le and Biggerstaff، نويسنده , , John and Townsend، نويسنده , , David، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
4
From page
6429
To page
6432
Abstract
To develop a small molecule-based biomarker for in vivo apoptosis imaging, a dansyled amino acid derivative (BNSBA) was designed and synthesized in good yield. The biological evaluation demonstrated that BNSBA selectively binds to apoptotic cancer cells and is localized within the cytoplasm of cells that bound annexin V on the plasma membrane.
Keywords
Amino acid , Imaging , Biomarker , apoptosis
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861441
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