Title of article
Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase
Author/Authors
Gallienne، نويسنده , , Estelle and Muccioli، نويسنده , , Giulio G. and Lambert، نويسنده , , Didier M. and Shipman، نويسنده , , Michael، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6495
To page
6497
Abstract
Monothiohydantoin 3a is made in seven steps from 1,4-diiodobenzene and is shown to be an inhibitor of fatty acid amide hydrolase (IC50 = 23.4 ± 1.1 μM). The key step in the sequence involves a microwave-assisted four-component reaction that makes the 5,5′-disubstituted hydantoin nucleus by the sequential formation of two C–C and two C–N bonds.
Keywords
FAAH , Thiohydantoins , Bucherer–Bergs reaction , Multi-component reactions , Microwaves
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861478
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