Title of article :
New synthetic method for 2,3-trans-2-methyl-tetrahydropyran-3-ol and oxepan-3-ol by unique insertion of a methyl group
Author/Authors :
Kimishima، نويسنده , , Atsushi and Nakata، نويسنده , , Tadashi، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Treatment of tetrahydropyran-3-ol and oxepan-3-ol derivatives, which have a 1′-mesyloxy group at the C-2 side chain, with Me3Al effected removal of the mesyloxy group, 1,2-hydride shift, and stereoselective insertion of a methyl group into the resulting oxonium ion, giving 2,3-trans-2-methyl-tetrahydropyran-3-ol and oxepan-3-ol derivatives, respectively.
Keywords :
Mesylate , Trimethylaluminum , 2-Methyl-oxepane , 2-Methyl-tetrahydropyran , polycyclic ether
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
