Author/Authors :
He، نويسنده , , Jing-Qian and Shibata، نويسنده , , Daisuke and Ohno-Matsui، نويسنده , , Chihaya and Okamoto، نويسنده , , Sentaro، نويسنده ,
Abstract :
Ketones 1 were converted to α-quaternary α-vinyl ketones 2 by a two-step formal allylic carbon insertion between ketone carbonyl and α carbons, which involves the reaction of 1 with propargyltitanium reagents, derived from propargyl carbonates 3 and a divalent titanium reagent Ti(O-i-Pr)4/2i-PrMgCl, and the following rearrangement of the resulting α-allenyl alcohols 4 with NBS.
