Title of article
Selective synthesis of 2-substituted pyridine N-oxides via directed ortho-metallation using Grignard reagents
Author/Authors
Andersson، نويسنده , , Hans-Ake Gustafsson، نويسنده , , Magnus G. Olsson، نويسنده , , Roger and Almqvist، نويسنده , , Fredrik، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
6901
To page
6903
Abstract
Addition of i-PrMgCl to pyridine N-oxides in THF at −78 °C generates selectively an ortho-metallated species, which can be trapped with various electrophiles to generate 2-substituted pyridine N-oxides. Furthermore, by applying a double metal-catalyzed cross-coupling, direct arylation of the pyridine N-oxides is achieved.
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861750
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