Title of article
PIFA-mediated synthesis of novel pyrazoloquinolin-4-ones as potential ligands for the estrogen receptor
Author/Authors
Christodoulou، نويسنده , , Michael S. and Kasiotis، نويسنده , , Konstantinos M. and Fokialakis، نويسنده , , Nikolas and Tellitu، نويسنده , , Imanol and Haroutounian، نويسنده , , Serkos A. Haroutounian، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2008
Pages
3
From page
7100
To page
7102
Abstract
A facile and efficient preparation of pyrazoloquinolin-4-ones, as potential ligands for the estrogen receptor, via a PIFA [phenyliodine(III)bis(trifluoroacetate)] promoted cyclization reaction with overall yields up to 29% over six steps is described. The employed strategy, based on an electrophilic amidation reaction as the key step of the synthesis, allows the generation of a diverse array of derivatives.
Keywords
PIFA , Quinolin-4-ones , Estrogen receptor , Pyrazole
Journal title
Tetrahedron Letters
Serial Year
2008
Journal title
Tetrahedron Letters
Record number
1861869
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