Author/Authors :
Velezheva، نويسنده , , Valeriya S. and Sokolov، نويسنده , , Andrey I. and Kornienko، نويسنده , , Albert G. and Lyssenko، نويسنده , , Konstantin A. and Nelyubina، نويسنده , , Yulia V. and Godovikov، نويسنده , , Ivan A. and Peregudov، نويسنده , , Alexander S. and Mironov، نويسنده , , Andrey F.، نويسنده ,
Abstract :
A highly efficient Lewis acid-catalyzed method for the Nenitzescu synthesis of 5-hydroxyindoles with a range of substituents at N-1 and C-3 and symmetric 5,5′-dihydroxydiindoles has been developed. The amount of the catalyst (10–100 mol %) required depended on the nature of the enaminone component. It has been shown that Lewis acid plays a role in enaminone component activation through an enamine-ZnC12 complex followed by its deprotonation.
