An easy and versatile synthesis of ureas from 2-benzylaminopyrimidine

A general procedure for the easy and versatile synthesis of ureas from 2-benzylaminopyrimidine is described. This methodology involves the preparation of a highly reactive carbamoyl chloride intermediate that can be further reacted with a high variety of different amines, including highly hindered secondary amines and deactivated anilines with excellent yields. Furthermore, this smooth procedure is compatible with a second functionality on the amine.