Title of article :
Topsentiasterol sulfates with novel iodinated and chlorinated side chains from the marine sponge Topsentia sp.
Author/Authors :
Guzii، نويسنده , , Alla G. and Makarieva، نويسنده , , Tatyana N. and Denisenko، نويسنده , , Vladimir A. and Dmitrenok، نويسنده , , Pavel S. and Burtseva، نويسنده , , Yuliya V. and Krasokhin، نويسنده , , Vladimir B. and Stonik، نويسنده , , Valentin A.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2008
Abstract :
Three new marine polar steroids, the first chlorine-containing steroid sulfate (1), topsentiasterol sulfate F (2) and the first natural iodinated steroid (3) have been isolated from the marine sponge Topsentia sp. The structures of 1–3 were elucidated using NMR and HRESIMS as well as by chemical correlation of 1 with previously known topsentiasterol sulfate D. Compound 1 proved to be an effective inhibitor of endo-1,3-β-d-glucanase from the marine mollusc Spisula sachalinensis.
Keywords :
3-?-d-Glucanase , endo-1 , 1D and 2D NMR , HRESIMS , Polyhydroxysteroid trisulfates , Chlorofuran , Iodofuran , Marine sponge , Topsentia
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
