Author/Authors :
Onose، نويسنده , , Jun-ichi and Yoshioka، نويسنده , , Yasukiyo and Ye، نويسنده , , Yue Qi and Sugaya، نويسنده , , Kouichi and Yajima، نويسنده , , Arata and Taniguchi، نويسنده , , Kayoko and Okada، نويسنده , , Kiyoshi and Yajima، نويسنده , , Shunsuke and Takahashi، نويسنده , , Shunya and Koshino، نويسنده , , Hiroyuki and Abe، نويسنده , , Naoki، نويسنده ,
Abstract :
Vialinin A is an extremely potent inhibitor of tumor necrosis factor (TNF)-α release from RBL-2H3 cells. The present study investigated in detail the inhibitory effects of vialinin A and its analog, 5′,6′-dimethyl-1,1′:4′,1″-terphenyl-2′,3′,4,4″-tetraol (DMT), on TNF-α. Vialinin A and DMT inhibited the release of TNF-α from RBL-2H3 cells in a dose-dependent manner, but had no effect on β-hexosaminidase activity. Also, vialinins had little effect on TNF-α mRNA levels. Intriguingly, vialinins inhibited TNF-α production at low concentrations, but not shown a dose-dependency. The potent inhibitory activities of vialinins against TNF-α production and release suggest promising new candidate pathways for anti-inflammatory agents.
Keywords :
cytokine , Vialinin A , Tumor necrosis factor (TNF)-? , RBL-2H3 cell
