Title of article :
MAOS protocols for the general synthesis and lead optimization of 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines
Author/Authors :
Aldrich، نويسنده , , Leslie N. and Lebois، نويسنده , , Evan P. and Michelle Lewis، نويسنده , , L. and Nalywajko، نويسنده , , Natalia T. and Niswender، نويسنده , , Colleen M. and David Weaver، نويسنده , , C. and Jeffrey Conn، نويسنده , , P. and Lindsley، نويسنده , , Craig W.، نويسنده ,
Abstract :
General, high-yielding MAOS protocols for the expedient synthesis of functionalized 3,6-disubstituted-[1,2,4]triazolo[4,3-b]pyridazines are described amenable to an iterative analog library synthesis strategy for the lead optimization of an M1 antagonist screening hit. Optimized compounds proved to be highly selective M1 antagonists.
