Author/Authors :
Pierry، نويسنده , , Camille and Zoute، نويسنده , , Ludivine and Jubault، نويسنده , , Philippe and Pfund، نويسنده , , Emmanuel and Lequeux، نويسنده , , Thierry and Cahard، نويسنده , , Dominique and Couve-Bonnaire، نويسنده , , Samuel and Pannecoucke، نويسنده , , Xavier، نويسنده ,
Abstract :
Grignard and organolithium reagents efficiently react with (S)-N-(tert-butanesulfinyl)-α-fluoroenimines to provide chiral allylamines in excellent yields and with diastereomeric ratios of up to 96:4. Acidic removal of the sulfinyl group and simple functional group transformations allow to get enantiopure fluoroolefin dipeptide mimics.
Keywords :
Peptides mimics , Fluorine compounds , Enimines , diastereoselective synthesis , Grignard
