Author/Authors :
Fish، نويسنده , , Paul V. and Mackenny، نويسنده , , Malcolm and Bish، نويسنده , , Gerwyn and Buxton، نويسنده , , Timothy and Cave، نويسنده , , Russell and Drouard، نويسنده , , David and Hoople، نويسنده , , David and Jessiman، نويسنده , , Alan and Miller، نويسنده , , Duncan and Pasquinet، نويسنده , , Christelle and Patel، نويسنده , , Bhairavi and Reeves، نويسنده , , Keith and Ryckmans، نويسنده , , Thomas and ، نويسنده ,
Abstract :
The (R)- and (S)-N-Boc-morpholine-2-carboxylic acids 9 and 10 were prepared using an enantioselective synthesis employing a highly selective enzyme-catalyzed kinetic resolution of racemic n-butyl 4-benzylmorpholine-2-carboxylate (11) as the key step. Acids 9 and 10 were then converted efficiently and stereoselectively to reboxetine analogs 3 and 4.
