Author/Authors :
Wu، نويسنده , , Hui and Chen، نويسنده , , Xiu-mei and Wan، نويسنده , , Yu and Ye، نويسنده , , Ling and Xin، نويسنده , , Haiqiang and Xu، نويسنده , , Hua-hong and Yue، نويسنده , , Cai-hui and Pang، نويسنده , , Li-ling and Ma، نويسنده , , Rui and Shi، نويسنده , , Da-qing، نويسنده ,
Abstract :
A Tröger’s base derivative (5,12-dimethyl-3,10-diphenyl-1,3,4,8,10,11-hexaazatetracyclo [6.6.1.02,6.09,13]pentadeca-2(6),4,9(13),11-tetraenes) was used as an efficient catalyst for the three-component Mannich reactions of aromatic aldehydes and aromatic amines with ketones in water at room temperature. This rapid reaction afforded the corresponding β-amino ketones in good yields with excellent stereoselectivity.
Keywords :
Tr?ger’s base derivatives , stereoselectivity , aqueous media , Mannich reaction
