Title of article :
First stereoselective total synthesis of Goniothalesdiol A
Author/Authors :
Yadav، نويسنده , , J.S. and Rami Reddy، نويسنده , , N. and Harikrishna، نويسنده , , V. and Subba Reddy، نويسنده , , B.V.، نويسنده ,
Issue Information :
هفته نامه با شماره پیاپی سال 2009
Abstract :
The first total synthesis of Goniothalesdiol A, isolated from the stems of Goniothalamus amuyon (Annonaceae) is reported. The C2 stereocentre and C3/C4 syn diol were created by a Sharpless kinetic resolution followed by acetonide formation. The tetrahydropyran ring was formed and the C6 stereocentre was fixed by intramolecular oxy-Michael addition.
Keywords :
Pyran , stereoselective , Epoxide opening , oxy-Michael addition , Chan alkyne reduction , Sharpless kinetic resolution
Journal title :
Tetrahedron Letters
Journal title :
Tetrahedron Letters
