One-pot multicomponent synthesis of 2,3-dihydropyrans: new access to furanose–pyranose 1,3-C–C-linked-disaccharides

An efficient synthesis of 2,3-dihydropyrans from different terminal alkynes was developed. The 2,3-dihydropyrans were obtained in a few minutes through a microwave-assisted multicomponent enyne cross-metathesis/hetero-Diels–Alder reaction. Starting from C-ethynyl-ribofuranose, a new multicomponent approach to furanose–pyranose 1,3-C–C-linked disaccharides was also developed.