Author/Authors :
Slocum، نويسنده , , D.W. and Reece، نويسنده , , Troy L. and Sandlin، نويسنده , , Rebecca D. and Reinscheld، نويسنده , , Thomas K. and Whitley، نويسنده , , Paul E.، نويسنده ,
Abstract :
An ortho-metalation protocol has been developed, which permits the survival of a bromine substituent in p-bromoanisole. Eight derivatives of the generated ortho-lithiated intermediate have been prepared. A neglected metalation concept is being explored here; one which proposes that minimizing the pKa difference between the aryl substrate and the conjugate acid of the metalating agent will lead to a regiospecific and selective metalation process.
