Author/Authors :
Zhao، نويسنده , , Yong and Huang، نويسنده , , Sheng-Xiong and Xiao، نويسنده , , Wei-Lie and Ding، نويسنده , , Li-Sheng and Pu، نويسنده , , Jianxin and Li، نويسنده , , Xian and Yang، نويسنده , , Li-Bin and Sun، نويسنده , , Han-Dong، نويسنده ,
Abstract :
A phytochemical investigation of Isodon pharicus led to the isolation of a novel asymmetric ent-kauranoid dimer, bispseurata F (1), and three new diterpenoids, pharicinins A–C (2–4). Their structures were elucidated by extensive spectroscopic analysis. Compound 1 features a unique linkage pattern of C-17 with C-11′ to connect the two monomers. A possible biogenetic pathway of 1 was also proposed. Compounds 3 and 4 exhibited moderate inhibitory activity against NB4 and SH-SY5Y cell lines.
Keywords :
Isodon pharicus , NMR data , cytotoxicity , Labiatae , Pharicinins A–C , Bispseurata F
