Title of article :
Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones
Author/Authors :
Humphries، نويسنده , , Paul S. and Balan، نويسنده , , Gayatri and Bechle، نويسنده , , Bruce M. and Conn، نويسنده , , Edward L. and Dirico، نويسنده , , Kenneth J. and Hui، نويسنده , , Yu and Oliver، نويسنده , , Robert M. and Southers، نويسنده , , James A. and Yang، نويسنده , , Xiaojing، نويسنده ,
Abstract :
We have developed a number of efficient protocols for the facile synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones. This synthetic methodology allowed concise and efficient exploration of the SAR in all areas of the molecule. A number of these methods proved to be versatile, efficient and amenable to parallel synthesis.
