Author/Authors :
Ali، نويسنده , , Asghar and van den Berg، نويسنده , , Richard J.B.H.N. and Overkleeft، نويسنده , , Herman S. and Filippov، نويسنده , , Dmitri V. and van der Marel، نويسنده , , Gijsbert A. and Codée، نويسنده , , Jeroen D.C. Codée، نويسنده ,
Abstract :
The methylsulfonylethoxycarbonyl (Msc) group is presented as a non-lipophilic, base-labile, participating protecting group for carbohydrate alcohols. It can be introduced using Msc–Cl and pyridine and is readily cleaved via β-elimination under mild basic conditions. Its fluorous counterpart, the perfluorooctyl propylsulfonylethoxycarbonyl (FPsc) group, is used in a ‘light fluorous’ trisaccharide synthesis sequence.
